| 146 | 0 | 71 |
| 下载次数 | 被引频次 | 阅读次数 |
目的：分析体育锻炼、炎症因子与抑郁的相关性，探讨炎症因子在体育锻炼影响抑郁的中介作用。方法：采用横断面研究，收集受试者一般情况，并通过Godin-Shephard闲暇时间体力活动调查表（Godin-Shephard Leisure Time Physical Activity Questionnaire,GSLTPAQ）和患者健康问卷抑郁量表（Patient Health Questionnaire9-item Scale,PHQ-9）对76名受试者进行调查。使用含有92种靶蛋白的Olink PEA炎症序列检测受试者血浆中的炎症因子水平。结果：(1)抑郁程度与体育锻炼呈显著负相关（r=-0.338,P<0.01）；促炎因子FMS样酪氨酸激酶3配体（FMS-Like Tyrosine Kinase 3Ligand,Flt3L）和CXC趋化因子配体11(Chemokine Ligand 11,CXCL11)的表达水平与抑郁程度呈正相关（r=0.302,0.301;P<0.01），而Flt3L和CXCL11表达水平与体育锻炼呈负相关（r=-0.279,-0.248;P<0.05）。(2)中介效应检验表明，体育锻炼对抑郁的直接效应显著，效应值为-0.128；同时存在显著间接效应，包括“体育锻炼→Flt3L→抑郁”和“体育锻炼→CXCL11→抑郁”两条路径，中介效应值分别为-0.030,-0.027。结论 ：体育锻炼有助于降低Flt3L和CXCL11两种促炎因子的水平，直接或间接地减轻抑郁程度。
Abstract：Objective:To investigate the correlations among physical exercise,inflammatory cytokines,and depression,and to explore the regulatory mechanism of inflammatory cytokines in the influence of physical exercise on depression.Methods:This cross-sectional study collected general information from subjects.A total of 76 subjects were assessed using the Godin-Shephard Leisure Time Physical Activity Questionnaire(GSLTPAQ)and the Patient Health Questionnaire 9-item Scale(PHQ-9).The levels of inflammatory cytokines in the plasma of the subjects were measured using the Olink PEA inflammation panel,which contains 92 target proteins.Results:(1)Depression was negatively correlated with physical exercise(r=-0.338,P<0.01).The expression levels of two proinflammatory cytokines:FMS-like tyrosine kinase 3 ligand(Flt3L)and Chemokineligand11(CXCL11),were positively correlated with depression(r=0.302,0.301;P<0.01),while the levels of Flt3 Land CXCL11 were negatively correlated with physical exercise(r=-0.279,-0.248;P<0.05)．(2) Mediation modeling analysis showed that the direct effect of physical exercise on depression was significant,with effect value of-0.128.Additionally,there were significant indirect effects through two pathways: "physical exercise→Flt3L→depression" and "physical exercise→CXCL11→depression",with effect value of-0.030 and-0.027.Conclusion:Physical exercise can reduce the levels of two proinflammatory cytokines,Flt3 Land CXCL11,and may directly or indirectly alleviate depression.
[1]Zhong Y,Schroeder E,Gao Y,et al.Social support,health literacy and depressive symptoms among medical students:An analysis of mediating effects[J].Int J Environ Res Public Health,2021,18(2):633-644
[2]McGrath J J,Al-Hamzawi A,Alonso J,et al.Age of onset and cumulative risk of mental disorders:A cross-national analysis of population surveys from 29 countries[J].Lancet Psychiatry,2023,10(9):668-681
[3]Marwaha S,Palmer E,Suppes T,et al.Novel and emerging treatments for major depression[J].Lancet,2023,401(10371):141-153
[4]Blom K,Forsell E,Hellberg M,et al.Psychological treatment of comorbid insomnia and depression:A double-blind randomized placebo-controlled trial[J].Psychother Psychosom,2024,93(2):100-113
[5]Wang M,Mou X,Li T,et al.Association between comorbid anxiety and depression and health risk behaviors among Chinese adolescents:Cross-sectional questionnaire study[J].JMIR Public Health Surveill,2023,9:e46289
[6]Arnaud A M,Brister T S,Duckworth K,et al.Impact of major depressive disorder on comorbidities:A systematic literature review[J].J Clin Psychiatry,2022,83(6):38-49
[7]McCarron R M,Shapiro B,Rawles J,et al.Depression[J].Ann Intern Med,2021,174(5):ITC65-ITC80
[8]Ross R E,VanDerwerker C J,Saladin M E,et al.The role of exercise in the treatment of depression:Biological underpinnings and clinical outcomes[J].Mol Psychiatry,2022,28(1):298-328
[9]Pearce M,Garcia L,Abbas A,et al.Association between physical activity and risk of depression:A systematic review and meta-analysis[J].JAMA Psychiatry,2022,79(6):550-559
[10]Schuch F B,Vancampfort D.Physical activity,exercise,and mental disorders:It is time to move on[J].Trends Psychiatry Psychother,2021,43(3):177-184
[11]Noetel M,Sanders T,Gallardo-Gomez D,et al.Effect of exercise for depression:Systematic review and network meta-analysis of randomised controlled trials[J].BMJ,2024,384:e075847.1-17
[12]马冀飞，王宏图，王晶晶，等．体育锻炼与中国老年人生活满意度的倒U型关系：抑郁的中介作用[J]．中国健康心理学杂志，2024,32(1):7-13
[13]Liu C,Chu D,Kalantar-Zadeh K,et al.Cytokines:From clinical significance to quantification[J].Adv Sci(Weinh),2021,8(15):e2004433.1-29
[14]Beurel E,Toups M,Nemeroff C B.The bidirectional relationship of depression and inflammation:Double trouble[J].Neuron,2020,107(2):234-256
[15]Harsanyi S,Kupcova I,Danisovic L,et al.Selected biomarkers of depression:What are the effects of cytokines and inflammation?[J].Int J Mol Sci,2022,24(1):578-602
[16]Ouchi N,Parker J L,Lugus J J,et al.Adipokines in inflammation and metabolic disease[J].Nat Rev Immunol,2011,11(2):85-97
[17]于晶晶，李晓雪，刘春，等．中国及全球1990—2021年抑郁疾病负担变化趋势[C].2024年全国运动增强体质与健康学术会议，中国浙江江山，2024:1-2
[18]Kroenke K,Spitzer R L,Williams J B.The PHQ-9:Validity of a brief depression severity measure[J].J Gen Intern Med,2001,16(9):606-613
[19]Godin G.The Godin-shephard leisure-time physical activity questionnaire[J].Health Fit J Canada,2011,4:18-22
[20]Amireault S,Godin G.The Godin-shephard leisure-time physical activity questionnaire:Validity evidence supporting its use for classifying healthy adults into active and insufficiently active categories[J].Percept Mot Skills,2015,120(2):604-622
[21]Calderon C,Gustems M,Obispo B,et al.The mediating role of exercise in depression and fatigue in patients with advanced cancer[J].Curr Oncol,2024,31(6):3006-3016
[22]Filatova E V,Shadrina M I,Slominsky P A.Major depression:One brain,one disease,one set of intertwined processes[J].Cells,2021,10(6):1077-1091
[23]张英杰，樊荣，翟笃谱，等．体育锻炼氛围对初高中生抑郁情绪的影响：社交焦虑和网络人际关系成瘾的链式中介作用[J]．中国健康心理学杂志，2025,33(1):1-8
[24]Smith P J,Merwin R M.The role of exercise in management of mental health disorders:An integrative review[J].Annu Rev Med,2021,72:45-62
[25]Schoenfeld T J,Swanson C.A runner's high for new neurons?Potential role for endorphins in exercise effects on adult neurogenesis[J].Biomolecules,2021,11(8):1077-1091
[26]Kiecolt-Glaser J K,Derry H M,Fagundes C P.Inflammation:Depression fans the flames and feasts on the heat[J].Am J Psychiatry,2015,172(11):1075-1091
[27]Ostrowski K,Rohde T,Asp S,et al.Pro-and anti-inflammatory cytokine balance in strenuous exercise in humans[J].J Physiol,1999,515(Pt 1):287-291
[28]Ferrer M D,Capo X,Martorell M,et al.Regular practice of moderate physical activity by older adults ameliorates their anti-inflammatory status[J].Nutrients,2018,10(11):1780-1792
[29]Cueto F J,Sancho D.The Flt3L/Flt3axis in dendritic cell biology and cancer immunotherapy[J].Cancers(Basel),2021,13(7):1525-1539
[30]Deckx N,Wens I,Nuyts A H,et al.Rapid exercise-induced mobilization of dendritic cells is potentially mediated by a Flt3Land MMP-9-dependent process in multiple sclerosis[J].Mediators Inflamm,2015,2015:158956
[31]Peters M,Solem F,Goldschmidt J,et al.Interleukin-6and the soluble interleukin-6receptor induce stem cell factor and Flt-3Lexpression in vivo and in vitro[J].Exp Hematol,2001,29(2):146-155
[32]Roske C,Nguyen T N B,Schwartz J J,et al.Immunological correlates of suicidality among adolescents with internalizing symptoms[J].Brain Behav Immun Health,2024,41:100866
[33]Wang J,Ouyang X,Zhu W,et al.The role of CXCL11and its receptors in cancer:Prospective but challenging clinical targets[J].Cancer Control,2024,31:10732748241241162
[34]Kim J W,Ahn M H,Jung J Y,et al.Role of chemokines CXCL9,CXCL10,CXCL11,and CXCR3in the serum and minor salivary gland tissues of patients with Sjogren's syndrome[J].Clin Exp Med,2024,24(1):133-143
[35]Yang L,Cao M,Tian J,et al.Identification of plasma inflammatory markers of adolescent depression using the olink proteomics platform[J].J Inflamm Res,2023,16:4489-4501
[36]Nie J,Fang Y,Chen Y,et al.Characteristics of dysregulated proinflammatory cytokines and cognitive dysfunction in latelife depression and amnestic mild cognitive impairment[J].Front Immunol,2021,12:803633
基本信息:
DOI：10.13342/j.cnki.cjhp.2026.02.002
中图分类号:R749.4
引用信息:
[1]赵金映,李亚红,周玉亮,等.体育锻炼对抑郁的影响：炎症因子的中介作用[J].中国健康心理学杂志,2026,34(02):167-172.DOI:10.13342/j.cnki.cjhp.2026.02.002.
基金信息:
湖北省重点研发计划项目（编号：2022BCA039）